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Epigenetics mainly studies the regulation of gene expression and heritable changes in traits without changes in nucleotide sequence. Common epigenetic modifications include DNA methylation, RNA methylation, and histone modifications. DNA methylation modification plays an important role in maintaining normal cell function, transmitting genomic imprinting, embryonic development, and tumorigenesis by inhibiting gene expression as one of the means of gene regulation. In recent years, it has been found that similar regulatory mechanisms exist on RNA. N6-methyladenosine (mA) is the most common modification in mRNA and lncRNA in eukaryotes, dynamic reversible in cells, and cancer development and metastasis, embryo development, lipid metabolism, and circular RNA translation. DNA damage repair, etc. are closely related, and have become a research hotspot of epigenetics.


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