Long non-coding RNA (lncRNA) is a type of RNA molecule that is more than 200 nt in length and does not encode a protein. Originally, lncRNA was considered to be a by-product of RNA polymerase II transcription and did not have biological functions. Studies have shown that lncRNA has a conserved secondary structure that interacts with proteins, DNA and RNA and is involved in the regulation of various biological processes such as chromatin modification, transcriptional activation or inhibition, post-transcriptional regulation, and induced molecular interference as miRNAs. Gene expression, etc. Therefore, lncRNA is a very broad and unknown field with great research value and significance.
How to conduct lncRNA research?
lncRNA mechanism
Which lncRNA silencing product is right for you?
RiboBio provides a variety of highly efficient lncRNA suppression tools such as LncRNA siRNA, LncRNA Smart Silencer, LncRNA ASO, etc.
| LncRNA siRNA | LncRNA Smart Silencer | LncRNA ASO | |
|---|---|---|---|
| Component | siRNA | Consists of 3 siRNAs and 3 ASOs | ASO |
| Function | Silencing extranuclear lncRNA | Simultaneous inhibition of nuclear or extranuclear target lncRNA | Depending on RNase H, silencing of cytoplasmic and nuclear lncRNA simultaneously |
| Stability | High stability and chemical modification can synthesize in vivo siRNA | Optimized design algorithms, innovative chemical modification, higher sensitivity and suppression efficiency | Chemically modified for higher stability and can be used directly in in vivo experiments |
| Mechanism | Double-stranded RNA, which forms a RISC by binding to an enzyme. RISC specifically binds to the target gene mRNA that matches its sequence and causes mRNA degradation, resulting in gene silencing. | Multiple mechanisms inhibit target RNA and increase the probability of silencing | Single-stranded RNA&DNA hybrids that rely on RNase H for function |
| Interference effect | Better | Excellent（After-sales redesign and synthesis service） | Better |
| Transfection reagent | riboFECT™ CP Reagent | riboFECT™ CP Reagent | riboFECT™ CP Reagent |
