MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs in eukaryotes that are approximately 17 to 25 bp in length. Since the discovery of miRNAs in 1993, advances and discoveries in the field of small RNA have overturned the scientific community’s understanding of gene regulation. From embryonic development, to apoptosis, and even tumor growth, miRNAs play an important role in a range of physiological and pathological processes. Various genetic, metabolic, infectious, and tumor-associated miRNAs provide new insights for scientists in pathological research. The perspective may be a reliable biomarker for disease, and scientists are actively seeking to treat disease interventions by altering the function of miRNAs and developing new in vivo delivery methods. miRNAs have recently been discovered to mediate cross-species evolution. With adaptation, more miRNAs remain to be explored.
How to conduct miRNA research?
miRNA production and mechanism
Hui Ling et al. Nature Reviews Drug Discovery 12, 847–865 (2013)