Ribobio passed ISO9001 and ISO13485 international quality management systems in 2013 and obtained oligonucleotides API production license from CFDA in 2016, which also has built the largest cGMP oligonucleotide API base in Asia.

The method for RNA synthesis is the same with DNA, however, it will be more difficult for RNA synthesis due to the low coupling efficiency of RNA base, easy product degradation and special protection needed. RiboBio has equipped with various specifications of automatic synthesizers, advanced purification instruments, which also has the rich RNA synthesis experience and already completed a set of RNA synthesis and purification technology that enable to provide RNA synthetic products with high quality. RNA synthetic products include Standard purification, PAGE purification and HPLC purification. Select the suitable one according to your experiment needs.

Advantages

1. Professional team: over 10 years of oligonucleotide manufacturing experience and successfully manufactured and delivered more than 1 million oligonucleotides
2. Enriched experience in chemical modifications: provide various chemical modifications and flexible customized services
3. Strict quality control: internationally accepted GMP standards and practices, in accordance with ISO, ICHQ7a and CFDA
4. Advanced facilities: world-leading instruments for synthesis, purification and analysis
5. Excellent project management: standard project management process with precise execution
6. Flexibility: multiple scales ranging from micrograms to kilograms to meet your needs

Selection Guidelines

Purification Specification

1. Standard Purification 

Use Standard purification to guarantee of 80% product purity, which is suitable for preparing short-stranded RNA including RNA linker, short-stranded RNA probe, siRNA, miRNA mimic, miRNA inhibitor, miRNA agomir, miRNA antagomir. When the RNA length is over 30mer, please use PAGE purification.

2. PAGE Purification

Use PAGE purification to guarantee of 90% product purity, which is suitable for preparing various long-stranded RNAs synthesis including ASO, long-stranded RNA probe, miRNA precursor. Surely, it can also be used for short-stranded RNA.

3. HPLC Purification

Use HPLC purification to guarantee over 95% product purity. With extremely high purity, it can only be suitable for short-stranded RNA purification.