RiboBio provides a human genome-wide siRNA library covering more than 20,000 genes in the human genome. Each gene uses optimized iCatch siRNA design algorithm to design 3 siRNA premixed for 3 targets. The library was stored in a 96-well PCR plate in a 0.5 nmol lyophilized state. Each plate was provided with 80 siRNA premixes, one for each gene, and 100 screens per well (working concentration is 50 nM). The siRNA library, with specific chemical modification, is detected by strict mass spectrometry for purity and sequence verification, to maximize the specificity and stability and reduce the off-target rate. The siRNA library allows for the simultaneous screening of hundreds of gene functions once in a time. RiboBio is one of the first companies in Asia to have a human genome-wide siRNA library, also offering industry-leading high-content analysis and high-throughput screening services, fully assist efficient functional genomics studies, and provide siRNA sub-libraries according to the type of gene of interest.

RNA Binding Protein (RBP) is an important class of proteins that interact with RNA by recognizing specific RNA binding domains and is widely involved in important biology such as RNA cleavage, transport, editing, intracellular localization and translation. In the process, RBP is currently a potential target area for the prevention and treatment of many terminal and major disease functions. RiboBio provides a RBP siRNA library covering 1199 important RBP genes of human genes. Each gene uses siCatch siRNA optimized design algorithm to design 3 siRNA premixed for 3 targets. The library was stored in a 96-well PCR plate in 0.25 nmol lyophilized powder. Each plate was provided with 80 siRNA premix, one for each gene, and 50 screens per well (working concentration is 50 nM). The siRNA library adopts specific chemical modification and undergoes strict MS purity detection and sequence verification to maximize the specificity and stability and reduce the off-target rate.

RiboBio provides up to 80 genOFF siRNA sub-libraries of important human genes, such as kinases, phosphatases, GPCRs, signaling pathways, ion channels, cell proliferation, apoptosis, and nuclear receptors, etc, offering flexible and diverse options. Each of these libraries was designed using siCatch siRNA optimization design. Three siRNA in premixed formats were designed for three targets. The library was stored in a 96-well PCR plate in 0.25 nmol lyophilized powder, each with 80 siRNA premix. The library undergoes rigorous MS purity and sequence verification to ensure superior specificity and silencing efficiency.

RiboBio can customize siRNA libraries of human, mouse, rat and other species according to the research your research requiements. Custom library allows more than 10 genes to be ordered, and even 3 targets for each gene according to customer needs , for example, you can choose 0.25 nmol/0.5 nmol/1 nmol*3 pairs (human, rat, mouse) and 1 nmol*1 pair (other species), etc.