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环状RNA(circRNA)是一种闭环的单链RNA分子,在细胞中发挥着多种重要作用,如调控转录,或者以ceRNA的方式调控miRNA的活性等等。pCE-RB-Mam环状RNA过表达载体,多克隆位点两翼高效促进RNA成环剪切的反向重复序列可使插入到多克隆位点中的序列转录后成环剪切,从而实现circRNA的过表达。

代表性客户文章
  • Yao Y, Zhou Y, Hua Q. circRNA hsa_circ_0018414 inhibits the progression of LUAD by sponging miR-6807-3p and upregulating DKK1[J]. Molecular therapy. Nucleic acids, 2021, 23: 783.
  • Zhou R, Shi L, Shan K, et al. Circular RNA-ZBTB44 regulates the development of choroidal neovascularization[J]. Theranostics, 2020, 10(7): 3293.
  • Chen T, Yu Q, Xin L, et al. Circular RNA circC3P1 restrains kidney cancer cell activity by regulating miR‐21/PTEN axis and inactivating PI3K/AKT and NF‐kB pathways[J]. Journal of cellular physiology, 2020, 235(4): 4001-4010.
  • Liu Y, Liu H, Li Y, et al. Circular RNA SAMD4A controls adipogenesis in obesity through the miR-138-5p/EZH2 axis[J]. Theranostics, 2020, 10(10): 4705.
  • Li J, Li P, Zhang G, et al. CircRNA TADA2A relieves idiopathic pulmonary fibrosis by inhibiting proliferation and activation of fibroblasts[J]. Cell death & disease, 2020, 11(7): 1-15.

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