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micrON™ miRNA agomir是经过特殊化学修饰的miRNA激动剂,通过模拟内源性miRNA 进入miRISC复合物来调节靶基因mRNA 的表达而发挥作用。与普通的miRNA mimic相比,miRNA agomir在动物体内具有更高的稳定性和miRNA活性,更易通过细胞膜、组织间隙而富集于靶细胞,它可以用系统全身或局部注射等方法进行给药。

产品优势

1、低毒性,全球领先的自主专利技术
2、经化学修饰,可直接注射于实验动物,无需转染试剂
3、相比于病毒载体,合成周期短,便于后续转化医学中核酸药开发
4、更稳定,更易通过细胞膜、组织间隙

技术支持


皮下移植SMMC-7721 细胞到NOD-SCID 小鼠,2 周后尾微静脉注射胆固醇修饰及Cy3 荧光标记的miR-199a agomir (使用脂质给药试剂),每3 天一次,共7 次。三周后进行microPET/CT 成像,agomiR-199a 处理后肝肿瘤吸收的[18F]FDG(氟代脱氧葡萄糖)减少,即肿瘤生长减缓。Zhang L, et al. EMBO J. 2015.


b. 以5u mol/kg 一天的剂量给一只小鼠静脉注射miR-125a agomir,21 天后小鼠脊髓进行HE 染色和Luxol Fast Blue 染色,结果显示miR-125a agomir 改善CNS 炎症和髓鞘脱失情况。Pan W, et al. Nat commun, 2015.


对M-KO 小鼠的右后肢腓肠肌进行肌肉注射0.02ml 20uM miR-329 agomir,左后肢注射CTR agomir(对照组),4 天后收集肌肉样本,结果显示miR-329 组DLK1 蛋白显著减少。Gao Y, et al. PNAS, 2015.

代表性客户文章
  • Zheng K, Hu F, Zhou Y, et al. miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease[J]. Nature Communications, 2021, 12(1): 1-16.
  • Sun Y, Wang Q, Zhang Y, et al. Multigenerational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p[J]. Journal of Hepatology, 2020, 73(3): 603-615.
  • Chen J, Liu A, Wang Z, et al. LINC00173. v1 promotes angiogenesis and progression of lung squamous cell carcinoma by sponging miR-511-5p to regulate VEGFA expression[J]. Molecular cancer, 2020, 19: 1-19.
  • Zhang S B, Lin S Y, Liu M, et al. CircAnks1a in the spinal cord regulates hypersensitivity in a rodent model of neuropathic pain[J]. Nature communications, 2019, 10(1): 1-16.
  • Hou Z, Qin X, Hu Y, et al. Longterm exercise-derived exosomal miR-342-5p: a novel exerkine for cardioprotection[J]. Circulation research, 2019, 124(9): 1386-1400.
  • Wang C, Xu W, An J, et al. Poly (ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2[J]. Nature communications, 2019, 10(1): 1-12.
  • Cui C, Wang Y, Liu J, et al. A fungal pathogen deploys a small silencing RNA that attenuates mosquito immunity and facilitates infection[J]. Nature communications, 2019, 10(1): 1-10.

订购产品

miRNA agomir
产品编号 产品名称物种目录价数量操作
miR40000830-4-5 micrON rno-miR-125b-5p agomir,in vivo,5nmolrat¥2,400.00
miR40000537-4-5 micrON mmu-miR-27a-3p agomir,in vivo,5nmolmouse¥2,400.00
miR40004715-4-5 micrON rno-miR-27a-5p agomir,in vivo,5nmolrat¥2,400.00
miR40004324-4-5 micrON mmu-miR-181d-5p agomir,in vivo,5nmolmouse¥2,400.00
miR40000140-4-5 micrON mmu-miR-128-3p agomir,in vivo,5nmolmouse¥2,400.00
miR40000157-4-5 micrON mmu-miR-145a-5p agomir,in vivo,5nmolmouse¥2,400.00
miR40000243-4-5 micrON hsa-miR-148a-3p agomir,in vivo,5nmolhuman¥2,400.00
miR40000246-4-5 micrON mmu-miR-122-5p agomir,in vivo,5nmolmouse¥2,400.00
miR40003326-4-5 micrON hsa-miR-663a agomir,in vivo,5nmolhuman¥2,400.00
miR40005887-4-5 micrON hsa-miR-1299 agomir,in vivo,5nmolhuman¥2,400.00
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miRNA agomir对照
产品编号 产品名称目录价数量操作
miR0190522040349 micrON agomir NC #22(正义链3cy3), 5nmol¥2,795.00
miR4N0000001-4-5 micrON agomir NC #22, in vivo, 5nmol¥1,920.00
miR4N0000002-4-5 micrON agomir NC #24, in vivo, 5nmol¥1,920.00
miR4N0000003-4-5 micrON agomir NC #19, in vivo, 5nmol¥1,920.00
miR04102-4-5 micrON agomir NC #22 (5Cy3), in vivo, 5nmol¥2,795.00
miR04103-4-5 micrON agomir NC #22 (5Cy5), in vivo, 5nmol¥2,795.00
miR04104-4-5 micrON agomir NC #22 (5FAM), in vivo, 5nmol¥2,795.00
miR04202-4-5 micrON agomir NC #24 (5Cy3), in vivo, 5nmol¥2,795.00
miR04203-4-5 micrON agomir NC #24 (5Cy5), in vivo, 5nmol¥2,795.00
miR04204-4-5 micrON agomir NC #24 (5FAM), in vivo, 5nmol¥2,795.00

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