常规siRNA

常规siRNA为常规化学合成的无化学修饰双链RNA，特异性靶点设计，覆盖人、小鼠、大鼠全基因组的所有基因，其他物种亦可定制，适合进行各种细胞RNAi实验。

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下载说明书

重要提示：常规siRNA设计定制，碱基数19个默认加悬垂，大于19个碱基需添加备注（是否加悬垂（dTdT））；化学修饰siRNA需添加备注修饰位置（3端或5端，正义链或反义链）。

产品优势

1、采用siCatch™ siRNA design智能设计；
2、通过系统性优化，保证靶点特异性；
3、均经过严格的质谱检测，保证siRNA质量和纯度；
4、只需溶解，即可直接用于实验。

哪种siRNA适合您？

单条siRNA不能保证沉默效率，初次筛选建议您订购单基因套装或者选购3-5条进行实验，提升实验效率，加快实验进度。

代表性客户文章

Shen L, Hu P, Zhang Y, et al. Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation[J]. Cell Metabolism, 2021.
Sun B, Yang X, Hou F, et al. Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency[J]. Nature Microbiology, 2021: 1-15.
Li S Y, Zhu Y, Li R N, et al. LncRNA Lnc‐APUE is Repressed by HNF4α and Promotes G1/S Phase Transition and Tumor Growth by Regulating MiR‐20b/E2F1 Axis[J]. Advanced Science, 2021: 2003094.
Wang S, Zheng Y, Li J, et al. Single-cell transcriptomic atlas of primate ovarian aging[J]. Cell, 2020, 180(3): 585-600. e19.
Lv H, Lv G, Chen C, et al. NAD+ metabolism maintains inducible PD-L1 expression to drive tumor immune evasion[J]. Cell Metabolism, 2021, 33(1): 110-127. e5.
Tang C, Xie Y, Yu T, et al. m 6 A-dependent biogenesis of circular RNAs in male germ cells[J]. Cell research, 2020, 30(3): 211-228.
Li Y, Xia L, Tan K, et al. N 6-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2[J]. Nature Genetics, 2020, 52(9): 870-877.
Shen Q, Chen Z, Zhao F, et al. Reversal of prolonged obesity-associated cerebrovascular dysfunction by inhibiting microglial Tak1[J]. Nature Neuroscience, 2020, 23(7): 832-841.
Dai J, Huang Y J, He X, et al. Acetylation blocks cGAS activity and inhibits self-DNA-induced autoimmunity[J]. Cell, 2019, 176(6): 1447-1460. e14.
Dai P, Wang X, Gou L T, et al. A translation-activating function of MIWI/piRNA during mouse spermiogenesis[J]. Cell, 2019, 179(7): 1566-1581. e16.
Zhang W, Wang G, Xu Z G, et al. Lactate is a natural suppressor of RLR signaling by targeting MAVS[J]. Cell, 2019, 178(1): 176-189. e15.
Xu M, Xu H H, Lin Y, et al. LECT2, a ligand for Tie1, plays a crucial role in liver fibrogenesis[J]. Cell, 2019, 178(6): 1478-1492. e20.

技术支持

常规化学合成siRNA多为19nt RNA + dTdT (3’悬垂)的RNA双链分子，未经任何化学修饰。

Sense：正义链，RNA，序列与靶序列相同；

Antisense：反义链，RNA，序列与靶序列互补；

dTdT：两端悬垂，DNA，均在3’端。

还支持各种特殊修饰或突变设计

图1 常规siRNA结构示意图

图2 化学合成siRNA单链LC-MS质控结果

订购产品

产品编号	产品名称	物种	目录价
siB0837165937-1-5	si-h-STAT3_002, Standard, 5nmol	human	¥589.00
siB160406112518-1-5	si-m-Cd274_004, Standard, 5nmol	mouse	¥589.00
siB09917111357-1-5	si-h-TP53_004, Standard, 5nmol	human	¥589.00
siB12127101403-1-5	si-h-ALKBH5_001, Standard, 5nmol	human	¥589.00
siB12127101538-1-5	si-h-ALKBH5_003, Standard, 5nmol	human	¥589.00
siB11331105721-1-5	si-h-MYC_001, Standard, 5nmol	human	¥589.00
siB11331105730-1-5	si-h-MYC_002, Standard, 5nmol	human	¥589.00
siB09731120743-1-5	si-h-TP53_003, Standard, 5nmol	human	¥589.00
siB08530151718-1-5	si-h-ATG5_005, Standard, 5nmol	human	¥589.00
siG000219854B-1-5	si-h-TMEM218_102, Standard, 5nmol	human	¥589.00